United States Patent Application 20020143036
Kind Code A1
Flygare, John A ; et al. October 3, 2002
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Pentafluorobenzenesulfonamides and analogs
Abstract
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: 1
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Inventors: Flygare, John A; (Burlingame, CA) ; Medina, Julio Cesar; (Belmont, CA) ; Shan, Bei; (Foster City, CA) ; Clark, David Louis; (Albany, CA) ; Rosen, Terry J.; (Burlingame, CA)
Correspondence Name and Address: TOWNSEND AND TOWNSEND AND CREW, LLP
TWO EMBARCADERO CENTER
EIGHTH FLOOR
SAN FRANCISCO
CA
94111-3834
US
Assignee Name and Adress: Tularik Inc.
So. San Francisco
CA
Serial No.: 972743
Series Code: 09
Filed: October 5, 2001
U.S. Current Class: 514/345; 514/352; 514/424; 514/426; 514/518; 514/602
U.S. Class at Publication: 514/345; 514/352; 514/424; 514/426; 514/518; 514/602
Intern'l Class: A61K 031/44; A61K 031/4015; A61K 031/40; A61K 031/255; A61K 031/18
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Claims
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What is claimed is:
1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula......... (snip) |
