Bioorg Med Chem Lett 2002 Nov 4;12(21):3051
A series of C-Terminal amino alcohol dipeptide Abeta inhibitors.
Garofalo A, Wone D, Phuc A, Audia J, Bales C, Dovey H, Dressen D, Folmer B, Goldbach E, Guinn A, Latimer L, Mabry T, Nissen J, Pleiss M, Sohn S, Thorsett E, Tung J, Wu J.
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Potent, small molecule Abeta inhibitors have been prepared that incorporate an alanine core bracketed by an N-terminal arylacetyl group and various C-terminal amino alcohols. The compounds exhibit stereospecific inhibition as demonstrated in an in vitro assay. |
