United States Patent Application 20020150934
Kind Code A1
Powers, Scott ; et al. October 17, 2002
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Diagnosis and treatment of cancer using mammalian pellino polypeptides and polynucleotides
Abstract
The present invention provides methods, reagents, and kits for diagnosing and treating cancer in a mammal, e.g., a human. This invention is based upon the discovery that Pellino 1 or 2 is overexpressed and/or amplified in cancer. Methods to detect cancer or a propensity to develop cancer, to monitor the efficacy of a cancer treatment, and to treat cancer, by inhibiting the expression and/or activity of Pellino 1 or 2 in a cancer cell are included.
Inventors: Powers, Scott; (Greenlawn, NY) ; Mu, David; (Jericho, NY) ; Xiang, Phil; (San Francisco, CA) ; Peng, Yue; (South Setauket, NY)
Correspondence Name and Address: TOWNSEND AND TOWNSEND AND CREW, LLP
TWO EMBARCADERO CENTER
EIGHTH FLOOR
SAN FRANCISCO
CA
94111-3834
US
Assignee Name and Adress: Tularik Inc.
South San Francisco
CA
94080
Serial No.: 041030
Series Code: 10
Filed: December 28, 2001 |
