T/FIF, a New Plateau Message Board

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Biotech / Medical : T/FIF, a New Plateau

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To: scaram(o)uche who wrote (1486)	10/24/2002 2:31:52 PM
From: tuck	Read Replies (1) of 2243

>>And why is this shocking (not!) immunogenicity just now -- after such an extended period of human testing -- coming to light?<< Indeed. A quick flip through PubMed got me a PII study of BTI-322 for GVHD (n=26). Dosing was probably different, population definitely so, bit FWIW, the relevant snips: "BTI-322 0.1 mg/kg rounded up to the nearest milligram was administered intravenously (IV) daily for 10 consecutive days." "No IgG or IgM anti-BTI-322 antibodies were found in the 26 samples tested after therapy." I join you in saying grrrrr. This is not a current holding for me, but it is for my Mom. Thank goodness I got ABSC right for her. Tempting to bottom fish BTRN for SCS alone. Cheers, Tuck

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