United States Patent Application 20020156023
Kind Code A1
Walling, Jacqueline Mary ; et al. October 24, 2002
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Lometrexol combination therapy
Abstract
The present invention provides compositions and methods for treating proliferative disorders using combination therapies of lometrexol and other therapeutically active agents. The methods include administration of lometrexol with one or more therapeutically active agents where lometrexol and the therapeutically active agent(s) are delivered in a single composition, where they are administered in separate compositions in a simultaneous manner, where lometrexol is administered first, followed by the therapeutically active agent(s), as well as where the therapeutically active agent(s) is delivered first, followed by lometrexol. In preferred embodiments, the therapeutically active agent(s) has antiproliferative properties.
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Inventors: Walling, Jacqueline Mary; (Bristol, GB) ; Webb, Heather Kay; (San Francisco, CA) ; Calvert, Alan Hilary; (Newcastle, GB) ; Newell, David R.; (Northumbria, GB)
Correspondence Name and Address: TOWNSEND AND TOWNSEND AND CREW, LLP
TWO EMBARCADERO CENTER
EIGHTH FLOOR
SAN FRANCISCO
CA
94111-3834
US
Assignee Name and Adress: Tularik Inc.
Two Corporate Drive
South San Francisco
CA
94080
Serial No.: 010740
Series Code: 10
Filed: December 5, 2001 |
