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Biotech / Medical : Neurogen (NRGN)

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To: scaram(o)uche who wrote (344)	11/15/2002 11:08:55 PM
From: scaram(o)uche	Read Replies (2) of 523

Proc Natl Acad Sci U S A 1982 Jun;79(11):3613-7 Specific recognition of the product of a transferred major histocompatibility complex gene by cytotoxic T lymphocytes. Woodward JG, Orn A, Harmon RC, Goodenow RS, Hood L, Frelinger JA. Mouse L cells transfected with a genomic clone containing the H-2Ld gene (8-5 cells) were shown to function as targets for H-2Ld-specific cytotoxic T lymphocytes (CTL). The CTL-mediated lysis of 8-5 cells was shown to be H-2Ld specific by the use of (i) CTL with restricted reactivity, (ii) unlabeled target inhibiton, and (iii) monoclonal antibody inhibiton. We also demonstrated that 8-5 cells could function as targets for antibody-plus-complement-mediated cell lysis. Specificity was confirmed by using H-2Ld-specific monoclonal antibodies. These experiments demonstrate that the gene products of a major histocompatibility complex genomic clone can be functionally expressed in a foreign cell and can mediate immunologically specific cellular interactions. that is, "hoarded baby rabbit serum"-mediated cell lysis.

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