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Biotech / Medical : Biotech Valuation
CRSP 55.11-2.6%Nov 7 9:30 AM EST

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To: Biomaven who wrote (7482)12/11/2002 10:41:29 PM
From: Vector1  Read Replies (1) of 52153
 
Peter,
I made a big bet on Coulter/CRXA over the years and lost(so far). I was convinced that the BEXXAR data was strong and that the was more efficatious than Zevalin with less bone marrow toxicity. What went wrong remains a great mystery to me and I am looking forward to the advisory committee hearing. If the FDA does not have a smoking gun in regard to the data then there should be hell to pay. NHL is a fatal disease and a significant number of refractory patients on BEXXAR have been disease free for many years. I believe one patient is going on 8 years. Moreover, trials have shown that BEX can be redosed, and is effective on patients who have failed Rituxan. With regard to the market I believe Bex has greater potential than Zev if approved. If I remember correctly a phase II in front line patients with a fludarabine Bex combo did very very well. I will look for the abstract but I think it was a Sloan Kettering trial. If approved for refractory patients many of the more aggresive treatment centers will use the drug off label in combo with fludarabine as a first line treatment.

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