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Biotech / Medical : Caliper Technologies - CALP

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To: tuck who wrote (78)	12/14/2002 1:19:25 PM
From: tuck	Read Replies (1) of 114

My take home points from that article: The next generation Sipper chips, with four and twelve sippers, are needed to address throughput limitations. The library chip is needed to address wasted reagent that puts usage close to conventional screening norms. Sticky compounds such as the control inhibitor used in Amgen's assay require long washing times -- here over four minutes -- to affect their thorough removal from the chip. So that if your assay doesn't require such compounds, it shows a definite throughput advantage over conventional HTS. Data quality in a properly designed assay is really good. So my take is that CALP is on the threshold of having a system that is widely commercially acceptable, but isn't quite there yet. While companies such as Fluidigm may have superior technology for producing chips, CALP may have an edge in getting commercially useful systems out there. Maybe a munch down the road would give us the best of both worlds. And we must remember that CALP technology has applications beyond HTS. Note this article giving an inside look at Millenium's use of Caliper systems (including what Caliper learned the collaboration): dddmag.com CALP is trading for way under cash, and it may merit a look. The post bubble disappointment over limited commercial acceptance to date of microfluidic systems has been priced in and then some. It seems to me that the library chip and the four and twelve siphon sipper chips can make them truly competitive with conventional HTS systems, so the question becomes "when will these hit the market place?" The 12 sipper system is supposedly due out this year, I will try to find a more exact date. The library chip is described here; it sounds a little further off. Again, I am digging for a more precise date. calipertech.com Cheers, Tuck

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