United States Patent 6,479,471
Jackson , et al. November 12, 2002
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NAALADase inhibitors
Abstract
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
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Inventors: Jackson; Paul F. (Bel Air, MD); Slusher; Barbara S. (Kingsville, MD); Tays; Kevin L. (Elkridge, MD); Maclin; Keith M. (Baltimore, MD)
Assignee: Guilford Pharmaceuticals Inc. (Baltimore, MD)
Appl. No.: 466059
Filed: December 17, 1999
(another example, turned up searching simply for "PSMA". Why am I doing this? Looking for tissue distribution of the antigen, given that there is an active program to use a PSMA vaccine. But I'm just beginning..... I don't know that the PMSA of progenics, MLNM et al. is the same PMSA of GLFD.) |
