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Biotech / Medical : Indications -- Psoriasis/Chronic Inflammation
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To: Icebrg who wrote (296)1/13/2003 7:11:58 AM
From: Icebrg   of 631
 
REMICADE FOR SJOGREN SYNDROME
ARTHRITIS AND RHEUMATISM, December 2002;46:3301-3303:

Johnson & Johnson’s Remicade (infliximab) demonstrated a positive treatment effect for patients with active primary Sjogren syndrome. Remicade is indicated in specific clinical scenarios in rheumatoid arthritis and Crohn disease. Sjogren syndrome is an autoimmune disease typically manifesting as the combination of dry eyes, dry mouth, and another autoimmune disease of connective tissues such as rheumatoid arthritis (typically), lupus, scleroderma, or polymyositis.

Belgian researchers had conducted a 3-month pilot study of 16 patients treated with infliximab 3 mg/kg administered in three separate infusions at weeks 0, 2, and 6. The safe therapy led to rapid, sustained improvements in clinical and functional outcomes studied. These results prompted the
investigators to extend the protocol, effectively testing an infliximab maintenance regimen, to additional infusions every 12 weeks for 1 year.

10 of the original 16 study subjects participated the maintenance program. The improved disease outcomes prompted by the original infusions lasted 9 weeks prior to symptom
reemergence, most commonly dry mouth. 3 subjects remained symptom-free for one year after the initial regimen. After 1 year of maintenance therapy, all 10 patients experienced statistically significant clinical improvements.

Comments: There are as far as I know no real treatment options available for people suffering from Sjogren's syndrome. So, these are good news indeed.
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