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Biotech / Medical : Cadus Pharmaceutical Corp. (KDUS)
KDUS 1.6000.0%Jul 2 5:00 PM EST
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To: scaram(o)uche who wrote (969)2/6/2003 1:12:39 AM
From: scaram(o)uche  Read Replies (1) of 1833
 
METHODS AND COMPOSITIONS FOR IDENTIFYING RECEPTOR EFFECTORS
Patent Number: US2003009022
Publication date: 2003-01-09
Inventor(s): KLEIN CHRISTINE A (US); MURPHY ANDREW J M (US); PAUL JEREMY (US)
Applicant(s): CADUS PHARMACEUTICAL CORP (US)
Requested Patent: US2003009022
Application Number: US19980201396 19981130
Priority Number(s): US19980201396 19981130; US19960587895 19960117; US19960689172 19960806; US19960582333 19960117; US19940322137 19941013; US19940309313 19940920; US19940190328 19940131; US19930041431 19930331

Abstract

The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screening of large numbers of polypeptides in a library to identify those polypeptides which induce or antagonize receptor bioactivity. The subject assays are particularly amenable for identifying agonists and antagonists for orphan receptors. In particular the present invention makes available novel ligand agonists of human formyl peptide receptor like-1 (FPRL-1) receptors. These novel ligand agonists are used in the assays of the invention to identify modulators of FPRL-1 receptor.
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