S&P,...
DMSO is not a benign carrier molecule,...the evidence is displayed for all to see in the papers you and others have brought to the thread in the last year. They show DMSO has effects on many cell systems and structures, and can suck in more molecules (good and bad) than just the diclofenac. The cells immediately below the application area are going to be flooded with DMSO on application. The concentration of DMSO in those cells will initially be very high, no doubt much higher than the LD50's mentioned in industrial safety documents. From papers published by DMX, the Pennsaid adsorption continues until the site of application is washed,...so it is not a transitory effect lasting only a few minutes.
There are at least two steps to Pennsaid activity, one is the absorption of the DMSO diclofenac conjugate through the dead skin cell layer and through cell plasma membranes into cell cytoplasm(this part is similar to the patch, buccal absorption, etc. mentioned by Kayne, attributed to me). These live cells will be flooded with DMSO initially, and then the DMSO diclofenac conjugate must be bundled up into vesicles before being accessible to the microtubule transport mechanism. Something in Pennsaid must also shut down normal exocytosis of the vesicles through the plasma membrane into the extracellular fluid, as this is generally thought to be the dominant transport mechanism used by the cell to rid itself of unwanted chemicals and waste products. To illustrate further, if the solution was ethanol with diclofenac, this conjugate quickly passes through the dead skin layer and into the live cells similarly to DMSO/diclofenac, but the cells quickly pass this mixture through the cell plasma membrane and into the extracellular space and eventually to the bloodstream. So ethanol + diclofenac selects one transport mechanism, and DMSO + diclofenac selects another.
In selecting for this alternate cell to cell transport mechanism, DMSO must have effects on the cell other than that of a passive carrier. DMSO also stops nerve impulses from travelling down nerve cells,...so it must somehow shut down the sodium channels that are responsible for an action potential. DMSO is a membrane perturber,..it changes the fluidity properties of the cell membrane,...so it could stop the nerve from firing by changing the membrane properties around the Na channel inactivating it , or it could act directly on the protein in some way. If you know how, please cite the papers.
Your assertion that an elderly person's skin will be able to take a four times daily dose of Pennsaid with no harm has not been published by anyone yet. If you can cite data indicating what the side effect profile and dermis layer of an elderly patients using Pennsaid four times a day for a few months or longer displayed in any Pennsaid study, please do, as it will solve this portion of the debate. Until then, there is no proof shown here that the skin of a elderly chronic Pennsaid user will regenerate normally, or not display a higher side effect profile. This must have been on the minds of the British drug agency, as they directed their doctors not to prescribe Pennsaid for chronic users (SH post over a year ago). It will also likely show up in the HC negotiations and it is likely one of the reasons why FDA deliberations have been so slow.
It is clear that the shareprice does not make sense if Pennsaid was the wonder drug the cult says it is. So it makes sense to question everything about the drug and the company. I see no reason to stop this just because you and I have bought in at current levels looking for a quick pop up on some news. To do that would turn me into something no better than a clone cultist pumper groupthink pig,...I would rather remain a skeptic.
Kayne,...
Typical reactionary posts from the thread nazi,...take a few lines of a past series of posts out of context and spin it to your own evil ends (ggggggggg) You have proved nothing about me,...but you continue to prove something about yourself.
One conclusion of mine presented rings true,...the shareprice does tell it all for now,...the majority are actually not with you as you say, as clearly trade volume and shareprice speak a different tale. At least the debate on SH is wide ranging and healthy,..unfortunate that you and a few others must continually attempt to badmouth anyone who disagrees with your spin on the observations over here and there. Shame, shame, shame! (ggggggggggg)
Good luck with your other investments. |
