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Biotech / Medical : New Brunswick Scientific Co., Inc. (NBSC)

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To: scaram(o)uche who wrote (619)3/12/2003 9:11:38 AM
From: nigel bates  Read Replies (1) of 724
 
Sunesis If they can do this...
Message 18689503
...In addition, as reported in the PNAS study, the Company's scientists found adaptive sites in the target protein that are not evident upon inspection of x-ray crystal structure data of the native protein. They report that the IL-2 protein surface changed its conformation in the presence of tethered fragments. Dr. Wells commented, "These observations underscore the value and potential of an empirical process like Tethering to probe for adaptive binding sites on a target. Traditional structure-based approaches often do not provide sufficient insight for progressing potent leads against these more challenging but highly relevant disease targets."
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