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Biotech / Medical : SARS and Avian Flu
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To: Biomaven who started this subject4/4/2003 7:15:36 PM
From: tuck  Read Replies (1) of 4232
 
Haven't seen anything posted about the method used to ID a coronavirus as the culprit. Done by viral microarray.

sfgate.com

But lots of claims are being made, with Chinese CDC saying it's most likely a chlamydia strain that's the cause. That article didn't say a lick at how they arrived at that conclusion. Samples from 5 patients? So they carried a chlamydia strain. Did the Chinese challenge anyone with the isolated strain (Rhetorical; of course, they couldn't; could an animal model work?)? Did the patients not have any coronavirus or paramyxovirus or picornovirus? Is anyone sampling a large enough population? Say by putting the antibodies of the leading suspect viruses on microarrays and washing the sera of lots of patients over them, and doing the same with a large control group's sera (healthy controls, and controls with colds caused by various different viruses, etc.) to see which ones are differentially expressed? Just finding a new virus is apparently not hard, as we seem to be walking repositories of several different types, some of which have mutated into forms we haven't seen before.

I'm just not seeing much written about how the isolated viruses are being shown to be the cause of the symptoms.

Sure, we'll sequence some viruses. It would be nice if we sequenced the right one. It will be interesting to see how folks finally find the right culprit.

Cheers, Tuck
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