TGEN - Targeted Genetics Corporation Message Board

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Biotech / Medical : TGEN - Targeted Genetics Corporation

TGEN 8.230

+0.9%

Nov 7 9:30 AM EST

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To: tktrimbath who wrote (379)	5/11/2003 9:01:59 AM
From: Mike McFarland	of 557

The ASGT abstracts available at asgt.org-- there is AAV2/5 stuff, which for Tgen actually turned out backward from what you would expect, so I guess that it is interesting. And maybe bad--you probably want AAV5 to work better than AAV2, since (and I do not remember for sure if this is correct) ...since AAV2 is something we have all been exposed to alot, and you want a vector that is not going to provoke an immune response. I scanned for Targeted Genetics, and apparently Wilson still has some shares, so I happened to look at a Hemophillia Dog abstract with AAV2/8 serotype that has very good expression and no more bleeding after a second dosing. Thast is pretty nifty. Have fun slogging thru the abstracts. There must be a couple thousand authors listed in the index-- I don't thing we have seen the last of gene therapy! (Although we may be watching the last days of Tgen). I glanced at the Tgen report finally. I guess Elan can take over the company easier than Biogen. We are not likely to get our investments back on this one.

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