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Biotech / Medical : SARS and Avian Flu
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To: Biomaven who wrote (817)5/13/2003 3:44:02 PM
From: Biomaven  Read Replies (1) of 4232
 
The links to the Science paper I referenced are freely available online:

sciencemag.org./feature/data/sars/

Here's the conclusion from the protease structure paper (an amazing piece of work by everyone given the time constraints):

Conclusions
The three-dimensional structures presented here for
coronavirus main proteinases provide a solid basis for the
design of anticoronaviral drugs. The binding modes of
substrates and peptidic inhibitors is revealed by the crystal
structure of TGEV M pro in complex with the hexapeptidyl
chloromethyl ketone. In spite of large differences in binding-
site architecture of the target enzymes, compound AG7088
binds to human rhinovirus 3C pro in much the same orientation
as seen for the chloromethyl ketone compound in the binding
site of TGEV M pro . This surprising finding indicates that
derivatives of AG7088 might be good starting points for the
design of anticoronaviral drugs. Since AG7088 is already
clinically tested for treatment of the "common cold" (targeted
at rhinovirus 3C pro ), and since there are no cellular
proteinases with which the inhibitors could interfere,
prospects for developing broad-spectrum antiviral drugs on
the basis of the structures presented here are good. Such
drugs can be expected to be active against several viral
proteinases exhibiting Gln¼°.áôê[ (Ser,Ala,Gly) specificity,
including the SARS coronavirus enzyme.

(Some of the special characters don't come across properly on SI).

Peter
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