Sirna Therapeutics Reports First Quarter Financial Results
  Wednesday May 14, 8:55 am ET 
  BOULDER, Colo., May 14 /PRNewswire-FirstCall/ -- Sirna Therapeutics, Inc. (Nasdaq: RNAI - News) today reported a net loss applicable to common stock of $5.5 million, or $1.62 per share for the quarter ended March 31, 2003 compared to a net loss applicable to common stock of $8.5 million, or $2.55 per share for the same period in 2002. The decrease in net loss for the period was primarily attributable to a reduction of research and development expenses as a result of the company's new business strategy and previously announced organizational restructuring. Research and development expenses for the first quarter of 2003 were $3.8 million, compared to $6.7 million for the first quarter of 2002. Per share amounts have been adjusted to reflect the 1 for 6 reverse stock split which became effective on April 17, 2003.
  The company's cash, cash equivalents and securities available-for-sale were $4.9 million at March 31, 2003. On April 21, 2003 the company consummated a private placement of $48 million of its common stock and warrants exercisable for additional shares of common stock to a leading group of biotechnology venture capital investors to support the company's research and development of RNAi-based therapeutics. After consideration of the private placement, Elan's conversion of its preferred stock to common stock and a reverse common stock split, the company's total common shares outstanding is 28,227,709.
  About Sirna Therapeutics
  Sirna Therapeutics (formerly Ribozyme Pharmaceuticals) is a biotechnology company leveraging its expertise in nucleic acid technology to develop and commercialize products that target human diseases. Sirna Therapeutics' primary focus is to develop therapeutics based on a nucleic acid technology called ribonucleic acid interference, or RNAi. Sirna Therapeutics is listed on the Nasdaq National Market under the ticker symbol "RNAI." More information on Sirna Therapeutics is available on the company's web site at www.sirna.com .
  This press release contains forward-looking statements that involve risks and uncertainties, and actual events or results may differ materially. These risk factors include actions by the U.S. Food and Drug Administration, technological advances, ability to obtain rights to technology, ability to obtain and enforce patents, ability to commercialize and manufacture products and general economic conditions. These and additional risk factors are identified in the company's Securities and Exchange Commission filings, including the Forms 10-K and 10-Q and in other SEC filings.
  For further information please contact: Marvin Tancer, CFO & V.P. Operations of Sirna Therapeutics, Inc., +1-303-449-6500; or Amy Sullivan, Senior Vice President of Noonan Russo Presence, +1-415-677-4455, for Sirna Therapeutics, Inc. 
                               SIRNA THERAPEUTICS, INC.                              CONDENSED BALANCE SHEET
                                                     March 31,    December 31,                                                      2003          2002                                                  (unaudited)     Assets       Cash, cash equivalents and        securities available-for-sale              $4,866,645     $8,820,978       Accounts receivable                            385,493        483,645       Equipment & leasehold        improvements, net                           4,270,443      4,523,809       Other assets, net                            8,046,294      8,069,693     Total assets                                 $17,568,875    $21,898,125
      Liabilities and stockholders' deficit       Current liabilities                         $5,662,079     $5,033,196       Long-term liabilities, convertible        debt & redeemable preferred stock          20,995,025     20,818,078       Stockholders' deficit                       (9,088,229)    (3,953,149)
      Total liabilities & stockholders' deficit    $17,568,875    $21,898,125
                               SIRNA THERAPEUTICS, INC.                     (Formerly Ribozyme Pharmaceuticals, Inc.)                              STATEMENTS OF OPERATIONS                                    (Unaudited)
                                                       Three months ended                                                           March 31,                                                      2003           2002
      Total revenues                                  $489,789     $1,578,636
      Expenses       Research and development                     3,776,762      6,740,615       General and administrative                   1,389,439      1,482,609     Total expenses                                 5,166,201      8,223,224
      Operating loss                                (4,676,412)    (6,644,588)
      Total other expense                             (237,341)    (1,650,075)
      Net loss                                      (4,913,753)    (8,294,663)
      Accretion of dividends on preferred stock        562,388        202,916
      Net loss applicable to common stock          $(5,476,141)   $(8,497,579)
      Net loss per share (basic and diluted)      (split adjusted)                                $(1.62)        $(2.55)
      Shares used in computing      net loss per share (split adjusted)           3,380,893      3,335,840
 
  -------------------------------------------------------------------------------- Source: Sirna Therapeutics, Inc. |