<<BINGO part 2........oxgn news.>>
Maybe, there is something in OXGN candidate, but please, in future do not post *hype* news to me.
There are other lurkers on this board that may enjoy your post, not me. If you want my attention, do DD on news and provide informed comments.
Oxi4503 abstract (from previous work, difference is in tumor model, hemangioendothelioma versus adenocarcinoma):
Anticancer Res 2002 May-Jun;22(3):1453-8
Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503.
Hill SA, Toze GM, Pettit GR, Chaplin DJ.
Gray Cancer Institute, Mount Vernon Hospital Northwood, Middlesex, UK.
BACKGROUND: Tubulin depolymerizing drugs, which selectively disrupt tumour neovasculature, have recently been identified. The lead drug in this class, combretastatin A4 phosphate (CA4P), has just completed Phase I clinical trial. We have continued to synthesize and evaluate a number of combretastatins, with the aim of identifying novel agents that possess single agent activity. In the studies presented here we provide data on our lead preclinical compound and compare its antivascular and antitumour activity to that of CA4P in the murine breast adenocarcinoma CaNT. This compound, designated Oxi 4503, is the diphosphate prodrug form of combretastatin A1. RESULTS: At a dose of 1 mg/kg Oxi 4503 induced a greater than 50% reduction in functional vascular volume, which increased to 80% or more following doses of 10, 25 and 50 mg/kg. In contrast, CA4P induced approximately 40% vascular shutdown at 50 mg/kg, but had no measurable effect at 10 mg/kg. In addition to these vascular effects, Oxi 4503 at doses of 100, 200 and 400 mg/kg induced significant retardation in the growth of established CaNT tumours. No significant growth retardation was obtained with single doses of up to 400 mg/kg CA4P. CONCLUSION: In summary, these studies have identified Oxi 4503 as a preclinical development candidate with more potent antivascular and antitumour effects than CA4P when used as a single agent.
From today PR:
"Tumor growth was completely repressed at doses above 12.5 mg/kg, and clear evidence of tumor regression was seen in all animals at doses above 25 mg/kg," researchers reported in Anticancer Research. "In two out of ten animals treated with 25 mg/kg, complete tumor responses were documented with no evidence of recurrence at 3 months after the termination of treatment."
<< Enjoy the luck while it holds out! >>
If I put my fate in luck, I would be brook long time ago. But, I guess everyone needs luck from time to time.
Miljenko |
