U.S. patents issued in July (thus far).......
United States Patent 6,593,362
Steiner , et al. July 15, 2003
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Non-peptidic cyclophilin binding compounds and their use
Abstract
This invention relates to pharmaceutical compositions and methods of using non-peptidic cyclophilin-binding compounds in medical conditions involving breakdown of mitochondrial energy metabolism induced by calcium overload, in treating alopecia and promoting hair growth, in treating infections with filarial and helmintic parasites, and in treating and preventing infections with the human immunodeficiency virus.
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Inventors: Steiner; Joseph P. (Mt. Airy, MD); Hamilton; Gregory S. (Catonsville, MD)
Assignee: Guilford Pharmaceuticals Inc. (Baltimore, MD)
Appl. No.: 860756
Filed: May 21, 2001
United States Patent 6,600,010
Mao , et al. July 29, 2003
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Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same
Abstract
Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: ##STR1## wherein R is a divalent organic moiety; R' is an aliphatic, aromatic or heterocyclic residue; x is .gtoreq.1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
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Inventors: Mao; Hai-Quan (Towson, MD); Leong; Kam W. (Ellicott City, MD); Dang; Wenbin (Baltimore, MD); Lo; Hungnan (Shaker Heights, OH); Zhao; Zhong (Baltimore, MD); Nowotnik; David P. (Kingsville, MD); English; James P. (Chelsea, AL)
Assignee: Guilford Pharmaceuticals, Inc. (Baltimore, MD); John Hopkins University (Baltimore, MD)
Appl. No.: 921297
Filed: August 2, 2001
RELATED APPLICATIONS
This application is a continuation of U.S. Ser. No. 09/053,648, filed Apr. 2, 1998 now U.S. Pat. No. 6,322,797, which is a continuation-in-part of U.S. Ser. No. 08/832,215 filed Apr. 3, 1997 now abandoned, the specifications of which are hereby incorporated by reference in its entirety.
United States Patent 6,586,623
Tsukamoto , et al. July 1, 2003
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Thiol-based NAALADase inhibitors
Abstract
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-.beta. activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
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Inventors: Tsukamoto; Takashi (Ellicott City, MD); Majer; Pavel (Sykesville, MD); Stoermer; Doris (Baltimore, MD); Slusher; Barbara S. (Kingsville, MD)
Assignee: Guilford Pharmaceuticals Inc. (Baltimore, MD)
Appl. No.: 046917
Filed: January 17, 2002
Parent Case Text
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This application claims the benefit of U.S. Provisional Application No. 60/261,754, filed Jan. 17, 2001, and U.S. Provisional Application No. 60/342,772, filed Dec. 28, 2001, the entire contents of which applications are herein incorporated by reference. |
