Sirna Therapeutics Reports Second Quarter Financial Results
  Thursday August 14, 8:55 am ET
  BOULDER, Colo., Aug. 14 /PRNewswire-FirstCall/ -- Sirna Therapeutics, Inc. (Nasdaq: RNAI - News) today reported a net loss applicable to common stock of $7.8 million, or $0.28 per share, for the quarter ended June 30, 2003 compared to a net loss applicable to common stock of $9.6 million, or $2.85 per share, for the same period in 2002. Net loss applicable to common stock for the first six months of 2003 was $13.3 million, or $.084 per share, compared to a net loss applicable to common stock of $18.1 million, or $5.40 per share, for the same period last year. Per share amounts have been adjusted to reflect the 1 for 6 reverse stock split which became effective on April 17, 2003.
  The decrease in net loss for the period was primarily attributable to an increase in revenues from contract manufacturing plus lower operating expenses, reflecting the previously announced corporate restructuring and the Company's change in business strategy to focus primarily on RNA interference (RNAi) technology. Research and development expenses for the second quarter of 2003 were $4.3 million, compared to $7.9 million for the second quarter of 2002. Offsetting the revenue increase and savings in operating expenses, the Company took a one-time non-cash expense of $5.3 million in deferred patent costs for patents which do not directly support the Company's RNAi technology development focus.
  The Company's cash, cash equivalents and securities available-for-sale were $43.8 million at June 30, 2003. On April 21, 2003 the company consummated a private placement of $48 million of its common stock and warrants exercisable for additional shares of common stock to several biotechnology venture capital investors to support the Company's research and development of RNAi-based therapeutics.
  About Sirna Therapeutics
  Sirna Therapeutics (Nasdaq: RNAI - News) is using its proprietary technology and expertise in nucleic acids to develop a new class of nucleic acid-based therapeutics involving RNA interference. Sirna Therapeutics is dedicated to engineering RNA-based molecules for therapeutic and diagnostic purposes. More information on Sirna Therapeutics is available on the Company's web site at www.sirna.com.
  This press release contains forward-looking statements that involve risks and uncertainties, and actual events or results may differ materially. These risk factors include actions by the U.S. Food and Drug Administration, technological advances, ability to obtain rights to technology, ability to obtain and enforce patents, ability to commercialize and manufacture products and general economic conditions. These and additional risk factors are identified in the Company's Securities and Exchange Commission filings, including the Forms 10-K and 10-Q and in other SEC filings. Sirna undertakes no obligation to revise or update any forward-looking statements in order to reflect events or circumstances that may arise after the date of this release.
  For further information, please contact: Marvin Tancer, CFO & V.P. Operations of Sirna Therapeutics, Inc., +1-303-449-6500; or Amy Sullivan, Senior Vice President of Euro RSCG Life NRP, +1-415-901-3705.
                             SIRNA THERAPEUTICS, INC.                            CONDENSED BALANCE SHEET
                                                    June 30,       December 31,                                                     2003             2002                                                  (unaudited)     Assets       Cash, cash equivalents and        securities available-for-sale             $43,791,328     $8,820,978       Accounts receivable                            378,729        483,645       Equipment & leasehold        improvements, net                           3,948,372      4,523,809       Other assets, net                            2,835,386      8,069,693     Total assets                                 $50,953,815    $21,898,125
      Liabilities and stockholders'      equity (deficit)       Current liabilities                         $3,627,689     $5,033,196       Long-term liabilities, long-term debt &        convertible debt                            4,100,283      6,488,712       Convertible preferred stock                         --     14,329,366       Stockholders' equity (deficit)              43,225,843     (3,953,149)
      Total liabilities & stockholders' deficit    $50,953,815    $21,898,125
                               SIRNA THERAPEUTICS, INC.                         CONDENSED STATEMENTS OF OPERATIONS                                    (Unaudited)
                              Three months ended          Six months ended                                  June 30,                   June 30,                             2003         2002           2003        2002     Revenues       Collaborative        agreements     $2,877,120    $1,039,814     $3,261,909     $1,966,222       Collaborative        agreements-        joint venture          --       424,998          2,283        850,810       Collaborative        agreements-        related parties   105,398       157,441        208,115        383,857     Total revenues     2,982,518     1,622,253      3,472,307      3,200,889
      Expenses       Research and        development     4,276,230     7,886,618      8,052,993     14,627,233       General and        administrative  1,225,264     1,289,374      2,614,702      2,771,983       Deferred patent        cost write off  5,344,266            --      5,344,266             --     Total expenses    10,845,760     9,175,992     16,011,961     17,399,216
      Operating loss    (7,863,242)   (7,553,739)   (12,539,654)   (14,198,327)
      Other income      (expense)     Interest income      190,440       111,931        210,977        266,338     Interest expense     (83,633)     (266,102)      (208,099)      (602,890)     Other income      (expense)            (2,060)          740         (2,789)            70     Equity in loss of      unconsolidated      affiliate           (76,765)   (1,550,170)      (209,448)    (3,017,193)     Total other      income (expense)     27,982    (1,703,601)      (209,359)    (3,353,675)
      Net loss          (7,835,260)   (9,257,340)   (12,749,013)   (17,552,002)
      Accretion of      dividends on      preferred stock          --       300,856        562,388        503,772
      Net loss      applicable      to common      stock           $(7,835,260)  $(9,558,196)  $(13,311,401)  $(18,055,774)
      Net loss per      share (basic      and diluted)         $(0.28)       $(2.85)        $(0.84)        $(5.40)
      Shares used      in computing      net loss      per share        28,273,448     3,352,333     15,895,980      3,344,132
 
  Source: Sirna Therapeutics, Inc. |