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Pastimes : SARS - what next?
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To: Maurice Winn who wrote (699)8/27/2003 8:45:51 PM
From: Henry Niman  Read Replies (1) of 1070
 
Yes, its the same Country and its still in denial.

The mutation I previously described below is in the N gene at position 28268, but the region listed below for the N gene was 28768 - 29357 which would miss the mutation. However, there is another Frankfurt 1 mutation in the area. This one is at position 26600 which is in the M gene. The paper below indicated that 235 bp were sequenced in the M gene from 26427 - 26192, but usually the numbers are listed going up, so if the sequencing began at 26427 and went up 235 bp it would go to 26662 and would include the Frankfurt 1 mutation in the M gene.

I suspect that this is the mutation and although the details are different, the story is the same - the mutation traces back to the Metropole Hotel through the Singapore index case. Both Frankfurt 1 and FRA have the mutation at 26600. It is also shared with HKU-39849 which was isolated from the brother-in-law of the Metropole Hotel index case. The mutation is also found in TWC which was from a Taiwanese patient who had visited Amoy Gardens. The mutation is also in an unpublished isolate from a patient in Hong Kong. Thus, the mutation at 26600 actually has two ties to the Metropole Hotel (the Singapore index case and the brother-in-law of the Metropole Hotel index case) and is found in 5 SARS CoV isolates.

Thus, the story is the same. The Winnipeg labs have found two sequences that trace back to the Metropole Hotel, The Frankfurt 1 mutation does so through two who were at the Metropole Hotel or went on a shopping spree with the Metropole Hotel index case and Tor2 was from the son of the Toronto index case who also stayed at the Metropole Hotel.

Lab error for two SARS CoV sequences tracing back to the Metropole Hotel is hard to envision and the exact matches clearly did not come from OC43 and any other cold virus. They are clearly SARS CoV sequences and the likelihood of 2 SARS CoV sequences in 13 samples being reported because of lab error is several steps beyond remote.
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