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Pastimes : SARS - what next?
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To: Maurice Winn who wrote (734)9/10/2003 10:12:45 PM
From: Henry Niman   of 1070
 
The article below expresses some of the frustration with WHO's position on outbreaks that do not meet its expectations of how SARS CoV infections should present as well as the failure to provide a scientifically valid explanation of SARS CoV activity detected by reputable labs.

The case in Singapore offers a good opportunity for using molecular epidemiology to trace the origin of the infection. Sequencing of the virus will be most important. There are already 7 fully sequenced isolates from Singapore that are associated with the first outbreak. I am not sure if any of the clones handled on or about Aug 17 at the NEA are novel, but if they are, a comparison between the sequence of the virus handled then and the virus detected in the post-doc could be quite revealing.

Singapore seems to be ready and willing to get to the true cause of the illness and not willing to settle for scientific nonsense such as OC43 detection as an explanation of an exact match with TWO SARS CoVs.

Last week's Science article provides a broad spectrum of mutations that be analyzed with a relatively small amount of sequence data. Hopefully real data will come out of the investigation into the true origin of the SARS CoV detected in the post doc. I expect the Singapore investigation to be more thorough than the PR put out on the Vancouver outbreak.

>===== Original Message From "Henry L Niman, PhD" <henry_niman@hms.harvard.edu> =====
straitstimes.asia1.com.sg

SEPT 11, 2003
Better be forearmed: Treat the case as Sars
By Andy Ho
SENIOR CORRESPONDENT
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