United States Patent Application 20030166143
Kind Code A1
Klein, Christine A. ; et al. September 4, 2003
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Methods and compositions for identifying receptor effectors
Abstract
The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screening of large numbers of polypeptides in a library to identify those polypeptides which induce or antagonize receptor bioactivity. The subject assays are particularly amenable for identifying agonists and antagonists for orphan receptors. In particular the present invention makes available novel ligand agonists of human formyl peptide receptor like-1 (FPRL-1) receptors. These novel ligand agonists are used in the assays of the invention to identify modulators of FPRL-1 receptor.
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Inventors: Klein, Christine A.; (Salt Lake City, UT) ; Murphy, Andrew J.; (Cronton-On-Hudson, NY) ; Paul, Jeremy; (Nyack, NY)
Correspondence Name and Address: LAHIVE & COCKFIELD
28 STATE STREET
BOSTON
MA
02109
US
Serial No.: 277607
Series Code: 10
Filed: October 22, 2002
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation-in-part of U.S. Ser. No. 08/587,895, filed Jan. 17, 1996, and is a continuation-in-part of U.S. Ser. No. 08/689,172, filed Aug. 6, 1996, which is a continuation-in-part of U.S. Ser. No. 08/582,333, filed Jan. 17, 1996, which is a continuation-in-part of U.S. Ser. No. 08/322,137, filed Oct. 13, 1994, which is a continuation-in-part of U.S. Ser. No. 08/309,313, filed Sep. 20, 1994, now abandoned, which is a continuation-in-part of U.S. Ser. No. 08/190,328, filed Jan. 31, 1994, now abandoned, which is a continuation-in-part of U.S. Ser. No. 08/041,431, filed Mar. 31, 1993, now abandoned, the specifications of which are hereby incorporated herein by reference.
(181 claims) |
