SARS - what next? Message Board

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Pastimes : SARS - what next?

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To: Maurice Winn who wrote (773)	9/28/2003 4:47:06 AM
From: Henry Niman	Read Replies (2) of 1070

Here are a few tales of survivors. thestar.com Two were relatives of patients that died. I don't think that genetics was the key. Instead it was health and age. Most in Canada caught SARS in the hospital and most of the ones who died were older or had underlying conditions, which was pretty much across the board and around the world. You are trying to find a genetic component using a very small sample size without any actual data (you don't know the HLA haplotype of either those who died or those who survived). Genetics played a VERY small role. The data in the HLA paper was VERY weak and borderline significant in after the fact selection of subsets. Its like flipping a coin until you get 6 heads in a row and then saying that the odds against getting six heads is low, so the result is significant. I have not seen ANY conclusive data on HLA and the only data I know of was a VERY small study on a limited group in Taiwan. You are looking for something that you cannot see.

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