My comment>"important to remember that bpi-21 may be a ideal substitute for diseases were natural bpi is destroyed by antibodies to bpi.
BPI-21 is almost invisible to anca-bpi."
2003 paper below>
Antineutrophil cytoplasmic antibodies directed against bactericidal/permeability-increasing protein detected in children with cystic fibrosis inhibit neutrophil-mediated killing of Pseudomonas aeruginosa.
Sediva A, Bartunkova J, Bartosova J, Jennette C, Falk RJ, Jethwa HS.
Institute of Immunology, University Hospital Motol, V Uvalu 84 150 06, 5, Praha, Czech Republic. anna.sediva@lfmotol.cuni.cz
Antineutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) were repeatedly found in cystic fibrosis (CF) patients. We analyzed the effect of BPI-ANCA in inhibiting neutrophil-mediated killing of Pseudomonas aeruginosa. The bactericidal effect expressed as percentage of killed bacteria after 1 h incubation with neutrophils was 55% when the neutrophils were pretreated with normal human serum, ranged from 49 to 63% with the sera from control BPI-ANCA-negative groups and sharply decreased to the mean 30.5% (range 8-51%) in the presence of BPI-ANCA. Furthermore, the effect mediated by BPI-ANCA was dose dependent and reflected the titer of BPI-ANCA in tested sera |
