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Biotech / Medical : CNSI Cambridge Neuroscience

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To: Peter R Smith who wrote (10)7/27/1996 11:12:00 AM
From: John B. Anderson   of 675
 
To EHJE57A@prodigy.com Thanks for the information of Interneuron's drug. I did some research and it does appear that it is effective administered orally in ischemic stroke, as proven in a Phase III trial. It works by a different mechanism of action, somewhat as a TPA like clot-buster, but perhaps more importantly citicoline (IPIC's name for the drug) supplies chemicals the brain uses normally to make new brain cell membrane.

As to how this impacts CNSI is a very good question, which I will pose to Ed Hurwitz. I do know that CNSI's Cerestat works by a different mechanism of action, and while I'm no neuroscientist, I believe Cerestat works by blocking the flow of calcium ions into the damaged area of the brain, where these calcium ions -- the body's emergency damage limiting mechanism -- go way beyond the necessary repair in the area of stoke or traumatic brain injury, causing massive brain cell death.

Thanks again for the insight. That's the kind of help to each other this SI mechanism should promote! I'll post here the results of my conversation with Ed.

John_B_Anderson@prodigy.com
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