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Biotech / Medical : Cambridge Antibody Technology Group
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To: Jongmans who started this subject11/6/2003 11:07:30 AM
From: nigel bates   of 625
 
United States Patent Application 20020076692
Kind Code A1
Osbourn, Jane ;   et al. June 20, 2002
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Ribosome display
Abstract

The use in a ribosome display system for selection of a specific binding pair member (e.g. antibody molecule) able to bind a complementary specific binding pair member (e.g. antigen) of encapsidating specific binding member/ribosome complexes in a viral coat, optionally in combination with incorporation of an Midvariant RNA template and optionally one or more other improvements selected from: a glycine-serine tether, protein disulphide isomerase, protein disulphide isomerase in combination with oxidised and reduced glutathione at a ratio of between 1:1 and 10:1, addition of oxidised and reduced glutathione at a ratio of between 1:1 and 10:1 after 30 minutes of in vitro translation; blocking with heparin during selection.
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Inventors: Osbourn, Jane; (Cambridge, GB) ; Holet, Thor L.; (Frederikssund, DK)
Correspondence Name and Address:
TOWNSEND AND TOWNSEND AND CREW
TWO EMBARCADERO CENTER
EIGHTH FLOOR
SAN FRANCISCO
CA
94111-3834
US

Serial No.: 817661
Series Code: 09
Filed: March 26, 2001

U.S. Current Class: 435/5; 435/6; 435/7.1
U.S. Class at Publication: 435/5; 435/7.1; 435/6
Intern'l Class: C12Q 001/70; C12Q 001/68; G01N 033/53
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