Indications -- Psoriasis/Chronic Inflammation Message Board

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Biotech / Medical : Indications -- Psoriasis/Chronic Inflammation

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To: scaram(o)uche who started this subject	11/9/2003 11:32:29 PM
From: John McCarthy	of 631

3 Autoimmune Diseases Share a Genetic Defect, Scientists Find (note:SI won't post entire article - see link) Scientists have found an unexpected genetic link among three common autoimmune diseases: psoriasis, rheumatoid arthritis and systemic lupus erythematosus. The link among the three diseases involves a protein that helps the thymus gland train cells of the immune system. Autoimmune diseases are caused when such cells mistakenly attack the body's own tissues. The protein, Runx-1, controls the activity of various genes by binding to a nearby site on the DNA of the chromosomes. Last year, scientists at the University of Uppsala in Sweden reported that many patients with systemic lupus had an altered Runx-1 binding site on Chromosome 2, meaning that the Runx-1 protein could not properly control the gene next to the binding nytimes.com John McCarthy

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