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Biotech / Medical : Kos Pharmaceuticals, Inc (KOSP)
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To: AARON DIDICH who wrote (5)8/11/1997 7:02:00 PM
From: Tom D   of 118
 
Does anybody know the chemical name for Niaspan?

Aaron, I thought it would be easy to answer your question. Just run a medline on Niaspan. But I came up empty. If I can get the chemical name I will try again. I await a return call about this from IR at KOSP. I haven't even received my investor packet yet, so my information is still quite limited. It surprises me that the press releases don't include the chemical name. I wonder if it is just niacin in some drug delivery system which enhances its pharmacokinetics. If this is true, then your questions about the data on actual frequencies of adverse effects are inspired. It makes me wonder how much different and better this drug is than niacin. Particularly since it got through the FDA so quickly. I think I read the NDA was accepted in May and the drug approved in late July? You'd think they had the cure for cancer! Or JUST A REFORMULATION OF NIACIN. I will also ask IR, on their return call, to fax me a product insert.

Incidentally, I wonder if you might be better off on Lipitor. The 40 mg pills are now finally available from the pharmacies. You did not mention what your LDL's were. But 40 q day decreases triglicerides by 29% and drops the LDL 50%. If your LDL's are bad, lipitor could be better for you. I think the data on triglycerides as an independant atherosclerotic risk factor are so mixed that they don't matter a whole lot. Of course, you need to get the triglycerides out of the pancreatitis range. but a 29% decrease should do this. If LDL's are not an issue, then Niaspan would be better, since increasing the HDL is presumably beneficial. I actually am not aware if anybody has ever shown that increasing the HDL with niacin, or any pharmacologic therapy confers any benefits in terms of event reductions. Anybody know of good data on this? Certainly using alcohol to increase HDL is not salutary. Increasing HDL with exercise may be beneficial because of the exercise's improvement on cardiac myocontractility, and maybe not so much from the lipid effects. Best regards.

TDD
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