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Biotech / Medical : Somatogen (SMTG)

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To: jackie who wrote (252)	8/12/1997 9:57:00 PM
From: Mark Chavez	of 442

Hmm, Dose level will be the key in terms of usage. My point was that in a "bleed out" model, since a lot of the product can and does exit, the number of units used doesn't necessarily equate to the number of units left in the system in the "bleed out" model. Maximum allowable dose level is somewhat unclear with this model. Could one extrapolate a dosage level from a "bleed out" model? I do not know, but the number of units used in a "bleed out" model can not be consider the maximum dosage level. Another way to think about is to assume a four unit straight exchange between blood and a blood substitute with a 24 hour half-life. After two days, 75% of the blood substitute (i.e. three units) is no longer there. That's a lot of breakdown product and you'll need more blood. This is a grossly exagerated scenario just to show that dose level is an issue. A lot of blood substitute issues that are not well known are discussed in "Resuscitation and the Limited Utility of the Present Generation of Blood Substitutes", J. R. Hess and R. F. Reiss, Transfusion Medicine Reviews (1996), pp. 276-285. 130.14.32.43 It's a worthwhile read in terms of seeing things from another point of view. It's important to note that a lot of the toxicity issues are due to the hemoglobin being outside the red cell. With that in mind and with recombinant technology in hand, Somatogen may have the best chance as they can easily modify the hemoglobin. Gotta do your own homework... Mark.

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