Celltech Achieves Further Milestone In Osteoporosis Collaboration With Amgen
SLOUGH, U.K., Jan. 8, 2004 (PRIMEZONE) -- Celltech Group plc (LSE:CCH) (NYSE:CLL) today announces the achievement of a further milestone in its agreement with Amgen Inc (NASDAQ: AMGN - news) . for the research, development and global commercialisation of novel treatments for osteoporosis using Celltech (LSE: CCH.L - news - msgs) 's proprietary antibody fragment technology, which aims to identify antibody fragments against sclerostin, a protein discovered by Celltech. Sclerostin is involved in the regulation of bone deposition, and it is believed that by inhibiting this protein, bone loss in osteoporosis patients may be reversed.
Amgen and Celltech have completed their studies in certain disease models, triggering an undisclosed milestone payment to Celltech. This achievement follows rapidly on from a previous research milestone in October 2003.
Dr Melanie Lee, Research and Development Director for Celltech, commented: "We are delighted with the rapid progress being achieved by Amgen and Celltech scientists in this innovative programme, and continue to be highly encouraged by the data generated in studies to date."
Celltech Group plc (LSE:CCH) (NYSE:CLL) is one of Europe's largest biotechnology companies, with an innovative development pipeline funded by its profitable, cash-generative pharmaceutical business. Celltech also possesses drug discovery capabilities of exceptional strength, including a leading position in antibody engineering. More details can be found at www.celltechgroup.com
Notes for Editors
Osteoporosis
Osteoporosis is a degenerative bone disease estimated to affect one-third of women aged 60 to 70, and two-thirds of women aged 80 or older. Current treatments primarily halt loss of bone density, but do not reverse the effects of osteoporosis.
Amgen agreement
Key terms of Celltech's agreement with Amgen, announced in May 2002, are as follows:
-- Amgen has exclusive worldwide rights to develop and market treatments targeting the Sclerostin protein.
-- Celltech is responsible for the identification and engineering of high affinity PEGylated antibody fragments against the Sclerostin protein, using its SLAM technology and proprietary antibody fragment technology.
-- Celltech will pay a proportion of all early development costs.
-- Amgen will be responsible for worldwide development.
-- Celltech has the option to co-invest in late stage development and may then lead promotional activities in the European Union. Amgen will lead promotion in North America and Japan.
-- Alternatively, if Celltech chooses not to participate in development, Amgen will become the exclusive licensee for this program and will continue to develop and market products against the Sclerostin protein on a worldwide basis. Celltech would then receive royalties based on sales achieved by Amgen... |
