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Pastimes : SARS - what next?
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To: Maurice Winn who wrote (828)1/15/2004 6:44:51 PM
From: Henry Niman  Read Replies (1) of 1070
 
Actually, genetic studies in a disease like SARS have even more potential problems because it is passed by contact and can therefore go from one family member to another. The study had only 90 SARS patients and there were only 11 who had the susceptible HLA haplotype. If any of the 11 were related, that would skew the data since 3 were expected to be the HLA frequency in the general population, so you are really only talking about 8 cases over background. If there are 2-3 relatives, then the numbers start to get pretty small.
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