Indications -- Stroke Message Board

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Biotech / Medical : Indications -- Stroke

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To: russet who wrote (30)	1/19/2004 11:22:02 PM
From: John McCarthy	Read Replies (1) of 70

russett - terrific article - thanks for posting .... did a google search to try and find out what (if any) companies were using this ..... - could not find any trials .... - found universities/research ranging from Urvine CA Howard Huges Medical hhmi.org Homburg, Germany jbc.org - found 1 private company whose link is below ... i.e. at least they know how to spell it .... syntapharma.com - the following is way off but you never know .... there is a disease called (never heard of) HYPOCALCEMIA: DIAGNOSIS AND TREATMENT Chapter 7 - Lorraine A. Fitzpatrick, M.D. endotext.org now my point is - perhaps a company researching the disease might have some knowledge of TRPM7 but then again - maybe not .... <<<<<<<<<<< A rare finding is primary familial hypomagnesemia, which usually is diagnosed at a very young age. Hypomagnesemia with secondary hypocalcemia due to a mutation in TRPM6 was described simultaneously by 2 research groups 13,14. TRPM6 is a protein of the long transient receptor potential channel (TRPM) family and highly similar to TRPM7. TRPM7 is a bifunctional protein combining calcium- and magnesium-permeable cation channel activities with protein kinase activity. TRPM6 is present in both kidney tubules and intestinal epithelia and maps to chromosome 9q. This autosomal recessive disorder is treatable with life-long magnesium supplementation. Recognition and treatment can prevent long-term neurological defects. Patients can sometimes present in a triad of hypomagnesemia, hypokalemia, and hypocalcemia 15. <<<<<<<<<<< endotext.org lastly - and this is off the wall - these guys mention a research article about it as part of the research articles they use to talk about their product ... piercenet.com regards, John McCarthy

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