Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 196.08

-0.2%

3:59 PM EST

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To: Cheryl Galt who wrote (4802)	8/15/1997 9:19:00 AM
From: Henry Niman	of 32384

Cheryl, Although the interference concern is in the recent filing, it has been in LGND's filings for several years now (they just keep repeating the same info). Since LGND scientists DISCOVERED Panretin (9-cis retinoic acid or ALRT1057 or LGD1057) and showed that it was the orphan for RXRs, I think its pretty clear who will have the earliest data (which will determine who will prevail). The interference is really more bad news for Roche than LGND. Such interference is rather common on cutting edge science and in the US at least, earliest discovery date (laboratory notebooks) prevail and that date shouldn't even be close. Roche and JNJ have been working on tretinoin and isotretinoin (13-cis retinoic acid) for some time, but both compounds are specific for RARs. Panretin binds to RARs and RXRs (hence its name). Henry

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