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Biotech / Medical : Geron Corp.
GERN 1.495+9.5%11:39 AM EST
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To: r. peter Dale who wrote (117)8/16/1997 11:10:00 AM
From: maileg   of 3578
 
>>Two other things you should be aware of:
1) A hallmark of apoptosis is fragmented DNA: that is, as a result of a cell's suicide 'program', its DNA becomes 'scrambled' into smaller pieces. Researchers use this observation as a basis for detecting cells undergoing apoptosis (one common approach is the 'TUNEL' assay). An obvious question: can these assays be legitimately applied to cancer cells whose DNA tends to be scrambled even in the absence of apoptosis?>>

Is it so that cancer cells exhibit this phenomena as you describe? My understanding is that what you term "scrambled" DNA is actually DNA that's been cleaved between nucleosomes by a specific nuclease. So, are you saying that non-apoptotic cancer cells also have fragmented DNA (which means the cells are going to die anyway)?

Please clarify.

Thanks

Darci
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