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Biotech / Medical : Stem Cell Research

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To: SnowShredder who wrote (34)3/5/2004 6:54:01 AM
From: SnowShredder  Read Replies (1) of 495
 
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After 11 patients had been followed up for six months, it was found the seven who received stem cells plus G-CSF had improved heart function.

But five of the seven, and two of three who received G-CSF alone, experienced in-stent restenosis - where coronary artery narrows again, despite the stent treatment.

<snip>

I wonder if a drug coated stent would prevent this from happening? What is the frequency and time of restenosis in normal stent procedures? Found something...

biomedcentral.com

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The prevalence of ISR is estimated between 10% and 80%, depending on the definition used and several vessel- and patient-specific characteristics [6] ... The greatest tendency for the development of neointimal proliferation and ISR occurs between 1 and 3 months after the procedure, with minimal progression thereafter [9]. Between 6 months and 3 years after the procedure, there may be a slight improvement in luminal diameter [9,10]. Similarly, target site revascularization after the first year after coronary stenting occurs only sporadically [9,11]. The incidence and time course of restenosis after emergency coronary stenting are similar to those after elective stenting [12]."
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Best of Luck,

SS
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