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Biotech / Medical : XOMA. Bull or Bear?

XOMA 32.13

-0.5%

Nov 28 9:30 AM EST

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To: Robert K. who wrote (16710)	3/7/2004 2:03:16 PM
From: Robert K.	Read Replies (1) of 17367

Nurenburg trials> "At present we are working mainly on the function and expression of murine Bactericidal/Permeability Increasing Protein (BPI). BPI is a 55 kDa protein and is active via multiple mechanisms against Gram-negative bacteria. First, it displays direct antimicrobial activity against Gram-negative bacteria; second, it neutralizes lipopolysaccharide (LPS); and third, it opsonizes bacteria leading to enhanced phagocytosis. To date, the biologic functions of BPI have been limited to studies in humans; recently sequence information for mouse BPI became available, greatly expanding the opportunities to develop novel experimental systems. Chronic infections with Pseudomonas aeruginosa and subsequent inflammatory immune responses are key factors for the destruction of lung tissue of cystic fibrosis (CF) patients. Furthermore, during the onset of CF these patients develop autoantibodies with specificity to cytoplasmic proteins of neutrophils (anti-neutrophil cytoplasmic antibodies, ANCA). In up to 90% of the cases these ANCA are active against BPI. The presence of ANCA-BPI is strongly related to the colonization of the respiratory tract with bacteria of CF patients. Projects on this topic are dealing with the function and expression of BPI in the immune system and the role of BPI in the development of chronic inflammation in a mouse model of Pseudomonas aeruginosa infection." >http://www.uni-erlangen.de/docs/FAU/fakultaet/med/klimi/AG%20SCHNARE/TEXT_ENGLISH.htm

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