Rigel Pharmaceuticals, Inc. (RIGL) Message Board

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Biotech / Medical : Rigel Pharmaceuticals, Inc. (RIGL)

RIGL 35.20

-2.6%

Nov 7 9:30 AM EST

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To: mopgcw who wrote (188)	3/10/2004 12:30:29 PM
From: tuck	of 566

I don't recall Rigel mentioning a program in antimicrobials. . . . >>Bioorg Med Chem Lett. 2004 Mar 22;14(6):1423-6. The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria. Look GC, Vacin C, Dias TM, Ho S, Tran TH, Lee LL, Wiesner C, Fang F, Marra A, Westmacott D, Hromockyj AE, Murphy MM, Schullek JR. Rigel Inc., 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality.<< Cheers, Tuck

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