Imclone posters at AACR; quite a few "fully human" mAbs in there.
Is it the thought of newly rich IMCL's cash being thrown at DYAX mAbs that is behind the current strength ?
706 - Identification and characterization of a fully human antibody directed against epidermal growth factor receptor for cancer therapy
Meilin Liu, Haifan Zhang, Xenia Jimenez, Dale Ludwig, Larry Witte, Peter Bohlen, Dan J. Hicklin, Zhenping Zhu. ImClone Systems, New York, NY.
Growth Factors and Antibodies in Tumor Immunotherapy
Poster Session
Hall B4-D, Orange County Convention Center
Monday
8:00 AM -
12:00 PM 2209 - Potent anti-tumor activity of IGF-I receptor antagonist antibody IMC-A12 alone and in combination with CPT-11
Dale L. Ludwig, James R. Tonra, Douglas Burtrum, Marie Prewett, Rajiv Bassi, Andrea Hooper, Daniel S. Pereira, Bridget Finnerty, Eric Corcoran, Larry Witte, Daniel J. Hicklin. ImClone Systems Incorporated, New York, NY.
Immunotherapy and Combined Modality Approaches
Poster Session
Hall B4-D, Orange County Convention Center
Monday
8:00 AM -
12:00 PM 1809 - Regulation of heparanase expression and secretion by protein kinase A and protein kinase C
Hua-Quan Miao, Elizabeth Navarro, Frank Schmitges, Yaron Hadari, Peter Bohlen, Paul Kussie. ImClone Systems Incorporated, New York, NY.
Proteases and Protease Inhibitors
Poster Session
Hall B4-D, Orange County Convention Center
Monday
1:00 PM -
5:00 PM 2559 - Generation of a recombinant fully human bifunctional antibody that neutralizes both vascular endothelial growth factor receptor 2 and 3
Xenia Jimenez, Dan Lu, Laura Brennan, Kris Persaud, Meilin Liu, Huaquan Miao, Bronek Pytowski, Larry Witte, Zhenping Zhu. ImClone Systems, New York, NY.
Angiogenesis I: Inhibitors of VEGF and VEGF-Receptors
Poster Session
Hall B4-D, Orange County Convention Center
Monday
1:00 PM -
5:00 PM 2996 - A fully human anti-FLT3 antibody (EB10) is efficacious in leukemia models expressing either wild-type or ITD-mutant FLT3 receptor
Yiwen Li, Mei-Nai Wang, Hongli Li, Dan Lu, Rajiv Bassi, Haifan Zhang, Dale Ludwig, Paul Balderes, Obdulio Piloto, Donald Small, Larry Witte, Peter Bohlen, Zhenping Zhu, Daniel Hicklin. ImClone Systems, NY, NY and Johns Hopkins University School of Medicine, Departments of Pediatrics, Oncology, Baltimore, MD.
Novel Targets and Approaches for Angiogenesis and Signaling Pathways
Poster Session
Hall B4-D, Orange County Convention Center
Monday
1:00 PM -
5:00 PM 3005 - A fully human monoclonal antibody against VEGFR-1 inhibits growth of human breast cancers
Yan Wu, Zhaojing Zhong, Huiling Li, James Huber, Rajiv Bassi, Andrea Hooper, Bridget Finnerty, Xenia Jimenez, Henry Koo, Paul Balderes, Dale Ludwig, Paul Kussie, Larry Witte, Peter Bohlen, Daniel J. Hicklin. ImClone Systems Inc., New York, NY.
Novel Targets and Approaches for Angiogenesis and Signaling Pathways
Poster Session
Hall B4-D, Orange County Convention Center
Monday
1:00 PM -
5:00 PM 3049A - Conjugation of boron containing dendrimers to anti-EGF receptor monoclonal antibody cetuximab and its evaluation as a delivery agent for neutron capture therapy
Gong Wu, Rolf F. Barth, Weilian Yang, Madhumita Chatterjee, Werner Tjarks, Michael J. Ciesielski, Robert A. Fenstermaker. The Ohio State University, Columbus, OH, Roswell Park Cancer Institute, Buffalo, NY.
Novel Therapeutic Agents II
Poster Session
Hall B4-D, Orange County Convention Center
Wednesday
8:00 AM -
12:00 PM 5333 - Establishment of acquired resistance to epidermal growth factor receptor (EGFR) inhibitors in human tumor cell lines
Sergio Benavente, Shyhmin Huang, Eric Armstrong, Alexander Chi, Prakash Chinnaiyan, Paul M. Harari. University of Wisconsin-Madison, Madison, WI.
Growth Factor Receptors as Therapeutic Targets
Poster Session
Hall B4-D, Orange County Convention Center
Wednesday
8:00 AM -
12:00 PM 5353 - Antitumor activity of a novel, human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (IMC-11F8) in human tumor xenograft models
Marie Prewett, James R. Tonra, Bassi Rajiv, Andrea T. Hooper, Genevieve Makhoul, Bridget Finnerty, Larry Witte, Peter Bohlen, Zhenping Zhu, Daniel J. Hicklin. ImClone Systems Incorporated, New York, NY.
Growth Factor Receptors as Therapeutic Targets
Poster Session
Hall B4-D, Orange County Convention Center
Wednesday
8:00 AM -
12:00 PM 5354 - Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody
Dan Lu, Haifan Zhang, Dale Ludwig, Anita Persaud, Xenia Jimenez, Douglas Burtrum, Paul Balderes, Meilin Liu, Peter Bohlen, Larry Witte, Zhenping Zhu. ImClone Systems, New York, NY.
Growth Factor Receptors as Therapeutic Targets
Poster Session
Hall B4-D, Orange County Convention Center
Wednesday
8:00 AM -
12:00 PM 5065 - DEGA/AMIGO-2, a leucine-rich repeat family member differentially expressed in human gastric adenocarcinoma: Effects on ploidy, chromosomal stability and tumorigenicity
Daniel S. Pereira, Karen E. Rabenau, Jennifer M. O'Toole, Rajiv Bassi, Helen Kotanides, Dale L. Ludwig, Larry Witte. ImClone Systems Incorporated, New York, NY.
Molecular Alterations in Gastrointestinal Tumor Formation
Poster Session
Hall B4-D, Orange County Convention Center |
