Indications -- Stroke Message Board

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Biotech / Medical : Indications -- Stroke

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To: russet who wrote (30)	3/29/2004 8:30:05 PM
From: Peter H. Proctor	Read Replies (1) of 70

"The channel, called TRPM7, when activated causes brain cells to produce large quantities of free radicals - toxic molecules that break down the cell's DNA, proteins, and other components. Free radicals also cause TRPM7 to become even more active, causing massive overproduction of free radicals, resulting in death of the brain cell." TRPM7 or some related system likely plays a role in the action of nitrone drugs such as Cerovive, the disulfate derivative of PBN from Renovis. See nitrone.com . Peter H. Proctor, PhD, MD IP hit: Cerovive is the registered trademark for Astrazeneca's stroke drug NXY 059.

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