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Biotech / Medical : Indications -- diabetes

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To: scaram(o)uche who started this subject5/5/2004 2:20:59 PM
From: tuck  Read Replies (1) of 278
 
[Inhaled insulin -- antibodies a long term problem after all? ARDM, NKTR, AEGN; GNBT, EMIS]

Given ARDM/Novo's recent setback with respect to post-prandial blood glucose profiles:

Message 20078832

and the possible involvement of circulating antibodies previously thought to be not neutralizing:

Message 20079732

I have to wonder if inhaled insulin isn't really dead now. Which would make NKTR/PFE's Exubera a failure/short candidate (as they haven't released their data on this stuff -- or don't have it, and I'll bet the FDA AC will want it). And which would make Generex' (GNBT) buccal delivery system seem relatively promising, as it doesn't involve pulmonary delivery. Perhaps EMIS, too?

Further background, containing references:

eric.vcu.edu

medscape.com

medscape.com

Cheers, Tuck
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