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Biotech / Medical : Genta, Inc. (GNTA)

GNTA 2.300

+0.4%

Nov 7 9:30 AM EST

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To: Ken S. who wrote (1796)	5/5/2004 3:59:35 PM
From: Art Bechhoefer	of 1870

Ken, that data does NOT refute my comment on toxicity for the following reason. My understanding of antisense technology is that an antisense drug may inhibit an enzyme whose presence helps the body fight decarbazine, making that substance less effective. When administered with Genasense, the decarbazine drug may act as if it had been taken in a larger dosage without Genasense. So the effect of Genasense is to heighten the effects of decarbazine--good and bad--and to suggest that a better result might be obtained using a lower dosage of decarbazine in combination with Genasense. We may learn more about this at the conference call later this afternoon. Art

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