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Biotech / Medical : Geron Corp.

GERN 1.370

-2.1%

Dec 26 9:30 AM EST

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To: seminole who wrote (521)	8/21/1997 5:32:00 PM
From: louis mason	of 3576

Richard is right about the X-ray structure Marty, which is why I said I thought they were not going to do any computer modeling- which would only be possible after the crystal structure was solved- which it ain't. To be honest, even if it is- which will get somebody a science paper i think, i'm not sure it will be that valuable. Most of the modeling that I have seen being useful has been done with DNA-interacting drugs. This leaves them again at square one- run a ton of mind-less screens & hope for the best. Narrow it down some by using RT inhibitors or whatever anti-polymerase specific group of compounds- but its a shot in the dark anyway. By the way I will add this- there is another company that has many anti-telomerase leads (as does GERN probably), and a second company that is capable & is considering what the phase I anti-telomerase trials will look like, and these events are less than "years" away. louis mason.

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