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Biotech / Medical : Kosan BioSciences -- KOSN
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To: tuck who wrote (470)6/25/2004 8:11:51 AM
From: quidditch  Read Replies (1) of 933
 
Thanks, Tuck. I'm trying to figure out why KOSN would design the trial as a second line therapy after a first line therapy that has such associated toxicity. And then, as Peter points out, efficacy of oxaliplatin is marginal:

<The tumor response rate was similar in both groups. The percentage of patients with grade 3 distal paresthesia was lower in Ca/Mg group (7 versus 26%, P = 0.001). Acute symptoms such as distal and lingual paresthesia were much less frequent and severe (P = 10-7), and pseudolaryngospasm was never reported in Ca/Mg group. At the end of the treatment, 20% of patients in Ca/Mg group had neuropathy versus 45% (P = 0.003). Patients with grade 2 and 3 at the end of the treatment in the 85 mg/m2 oxaliplatin group recovered significantly more rapidly from neuropathy than patients without Ca/Mg.

quid
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