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Biotech / Medical : XOMA. Bull or Bear?

XOMA 31.80

-0.1%

Nov 21 9:30 AM EST

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To: Robert K. who wrote (17002)	7/3/2004 12:28:44 PM
From: Robert K.	Read Replies (1) of 17367

FILED in 2003 (not issued) FILED in 2003 >0001] The present invention relates generally to small peptide-based constructs that have 8 to 15 amino acid moieties. The sequences of these peptide-based constructs are designed and prepared based on a reverse subsequence (99-85) derived from amino acids identified and selected from Domain II of bactericidal permeability-increasing protein (BPI). The invention further relates to therapeutic uses of such peptide-based constructs due to their properties of heparin binding and neutralization, inhibition of endothelial cell proliferation and/or inhibition of angiogenesis, e.g., inhibition of in vivo neovascularization, including in models of chronic inflammatory disease states and metastatic tumors.

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