Chemokines and their Receptors Message Board

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Biotech / Medical : Chemokines and their Receptors

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To: nigel bates who wrote (63)	7/26/2004 1:02:47 PM
From: keokalani'nui	of 70

NBIX CCR7/CCL21 and CXCR4/CXCL12 for cancer Semin Cancer Biol. 2004 Jun;14(3):181-5. Related Articles, Links Chemokines in neoplastic progression. Zlotnik A. Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA. azlotnik@neurocrine.com Chemokines and their receptors have emerged as attractive targets regulating the migration of tumor cells in vivo, a process known as cancer metastasis. The control of metastasis is critical to the control of cancer progression. Two chemokine receptors and their ligands stand out as likely targets for therapeutics: CCR7/CCL21 for lymph node metastases, and CXCR4/CXCL12 for lung, liver, bone marrow, and brain metastases. The most widely expressed chemokine receptor among cancers is likely to be CXCR4.

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