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Biotech / Medical : Pharmacopeia, Inc. (ACCL) (Prev: PCOP)
ACCL 4.028+0.7%3:59 PM EST
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To: tommysdad who wrote (21)8/24/1997 11:44:00 PM
From: Czechsinthemail   of 179
 
IMHO, the "pool and split" approach is going to prove to be more important for finding and verifying lead structures. The "parallel" approach, I think, will be more important for optimizing that lead structure into a drug.

tommysdad,

Thanks for the reply. If "pool and split" is likely to generate more leads, does that suggest that PCOP will likely develop the larger library of compounds that in turn will generate more partnerships and more leads? On the Pharmacopeia website, they suggested their tagging approach was likely to reveal more analogs from which viable leads could be generated--presumably by organizing and categorizing the various tagged compounds. I gather that the number of compounds that can be generated via the "pool and split" method is enormous. Are combichem libraries somewhat like genomics libraries in that bigger is better? And presumably the corollary of easier to index is better?

I imagine that the parallel testing might be better for those compounds that would in some way be contaminated or altered by being mixed. It is the part of the "pool and split" approach that I have a hard time grasping.

I would very much appreciate hearing your evaluation of the different combichem companies. Thanks again.

Baird
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