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Biotech / Medical : Kosan BioSciences -- KOSN

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To: scaram(o)uche who wrote (480)	11/14/2004 8:26:05 AM
From: nigel bates	Read Replies (1) of 933

Would this point towards a rationale for pursuing an antibody approach to HSP90 inhibition ? (Nature freebie...) nature.com Nature Cell Biology 6, 479 - 480 (2004) doi:10.1038/ncb0604-479 Hsp90 invades the outside Didier Picard Didier Picard is in the Département de Biologie Cellulaire, Université de Genève, Sciences III, 30, quai Ernest-Ansermet, CH - 1211 Genève 4, Switzerland. Picard@cellbio.unige.ch Metalloproteases are required for the invasive nature of cancer cells. Surprisingly, the cytosolic molecular chaperone Hsp90 is now shown to promote maturation of the extracellular metalloprotease MMP2. This finding extends the multiplicity of roles assigned to the Hsp90 family to a new function outside the cell.

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