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Biotech / Medical : Pharmos (PARS)

PARS 2.700

+13.6%

Jan 21 4:00 PM EST

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To: gfp927z who wrote (1315)	11/25/2004 9:39:59 AM
From: Clarksterh	of 1386

For the Phase 2 TBI study, did Pharmos release the actual data / detailed summary of the data (one that was more detailed than their press release)? Yes. Sort of. They put out a paper combining 2 of the 3 arms. See the thread below for discussions of that paper and their retrospective culling of data. Was the Phase 2 powered to show statistical significance? A Phase II has a different purpose - to work through the bugs and determine how to size the phase iii. I don't really think they knew what they would find coming out of Phase II. Also, in the Phase 3, does anyone know the % level of improvement they'll need in order to show statistical significance for the various endpoints? Good question. 800+ patients is a lot. I suspect they could find even a 1/2 GOSE category improvement with stat sig, but I haven't worked the numbers. BTW - first read your questions as being inre the P II CABG. But updated this post to correct for my misread. Clark

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