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Biotech / Medical : SIBIA Neurosciences (SIBI)
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To: scaram(o)uche who wrote (64)8/30/1997 3:46:00 AM
From: scaram(o)uche   of 579
 
This (old article) gives you a clue to why SIBI is screening against a VGCC that was pulled back from the last Lilly renewal. They apparently believe that they have the correct receptor in-hand. Many annual meetings are a waste of time. This one was brief and lacking in detail, but there were a few gems..........

Migraine Gene Discovered

LIVERMORE, Calif.-Nov. 1, 1996 -- Dutch researchers working with human
patient studies and using chromosome fragments from Lawrence Livermore
National Laboratory have identified a gene that may hold a key to
understanding and eventually treating migraine headache.

Scientists working at Leiden University in The Netherlands have discovered
an abnormally structured gene in people suffering from a rare inherited
form of migraine called familial hemiplegic migraine. Researchers believe
knowledge gained in studying this new gene will help understand the cause
of other forms of migraine and will be important for the effort to develop
treatment for the condition.

The newly discovered gene resides on chromosome 19, the organization and
structure of which has long been studied by Lawrence Livermore Laboratory.
Three years ago, the Dutch researchers contacted Livermore scientists for
the physical map of the chromosome and for fragments of DNA from the region
of chromosome 19 in which the Dutch were interested. DNA are the molecules
that make up chromosomes.

The gene eventually discovered by the Dutch regulates the transport of
calcium into specific classes of brain cells. The movement of calcium into
these cells regulates the release of neurotransmitters, which are critical
elements in the network of communication among cells of the nervous system.

Migraine is a neurological disorder characterized by recurrent attacks of
disabling headache, vomiting and malaise. Approximately 24 percent of
females and 12 percent of males in the general population are affected by
some form of migraine. The children of familial hemiplegic migraine
sufferers have a 50-50 chance of also exhibiting the condition.

The Human Genome Center at Lawrence Livermore has mapped most of chromosome
19. A product of this research is a set of well-characterized DNA fragments
-- or clones -- spanning the chromosome. These clones are available for use
by the medical community for biological and medical research.

Lawrence Livermore, Los Alamos National Laboratory and Lawrence Berkeley
National Laboratory recently combined their human genome research efforts
within the U.S. Department of Energy's Joint Genome Institute.

The labs will work together and with other organizations to advance
knowledge of the basic structure of the entire human genome, or genetic
blueprint, through a coordinated high-throughput DNA sequencing effort.
The sequencing effort will increase the information content and utility of
the mapped clones.
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